Research Database
Comprehensive collection of peer-reviewed research on terpenes and their therapeutic applications. Our database focuses on evidence-based science with rigorous quality assessment.
Limonene Research Collection
Explore our curated database of limonene studies spanning from 1974 to 2021
Filter by Category
Our Research Methodology
Rigorous standards for study selection, evaluation, and quality assessment
Inclusion Criteria
- Peer-reviewed publications in reputable journals
- Studies focusing on limonene as primary or secondary compound
- Clear methodology and statistical analysis
- Human, animal, or in vitro studies with relevant endpoints
- Published in English with accessible abstracts
Quality Assessment
- Study design and methodology rigor (1-3 points)
- Sample size and statistical power (1-2 points)
- Control groups and blinding where applicable (1-2 points)
- Clinical relevance and translational potential (1-2 points)
- Reproducibility and validation (1 point)
Maximum score: 10 points
Data Extraction
- Standardized data collection forms
- Author information and institutional affiliations
- Study design, sample sizes, and duration
- Dosage regimens and administration routes
- Primary and secondary outcomes
- Safety profiles and adverse events
Quality Score Distribution
Research Timeline
Featured Research Highlights
Neuroprotective Potential of Limonene
Comprehensive systematic review demonstrating limonene's neuroprotective effects across multiple neurological conditions including Alzheimer's disease, multiple sclerosis, epilepsy, anxiety, and stroke.
Phase I Clinical Trial in Cancer Patients
First human clinical trial demonstrating safety and tolerability of oral D-limonene up to 8 g/m²/day in cancer patients, with partial clinical response observed in one breast cancer patient.
Citrus Peel and Skin Cancer Prevention
Epidemiological study showing significant association between citrus peel consumption (primary source of dietary limonene) and reduced risk of squamous cell carcinoma of the skin.